The Wyoming Valley is a historic industrialized region of Northeastern Pennsylvania. The region is historically notable for its influence in helping fuel the American Industrial Revolution with its many anthracite coal mines. As a metropolitan area, it is known as the Scranton–Wilkes-Barre metropolitan area, after its principal cities, Scranton and Wilkes-Barre…The Wyoming Valley is a historic industrialized region of Northeastern Pennsylvania. The region is historically notable for its influence in helping fuel the American Industrial Revolution with its many anthracite coal mines. As a metropolitan area, it is known as the Scranton–Wilkes-Barre metropolitan area, after its principal cities, Scranton and Wilkes-Barre. With a population of 567,559 as of the 2020 United States census, it is the fifth-largest metropolitan area in Pennsylvania, after the Delaware Valley, Greater Pittsburgh, the Lehigh Valley, and the Harrisburg–Carlisle metropolitan statistical areas.