Mapping of epitopes recognized by functional monoclonal antibodies (mAbs) is essential for understanding the nature of immune responses and designing improved vaccines, therapeutics, and diagnostics.

A recent study conducted at the University of Texas at Austin, USA, has identified a highly conserved neutralizing antibody binding site on the spike S2 domain of severe acute respiratory syndrome ...

Before Launching an Immune Intervention, Get the Lay of the Land Epitope mapping, which identifies antigen regions that serve as binding sites for antibodies, is starting to inform the discovery and ...

Epitope information is increasingly being used to understand the mechanism of action (MoA) of therapeutic monoclonal antibodies (mAbs), as well as to overcome the mounting challenges of patenting them ...

A team led by scientists at Weill Cornell Medicine, Scripps Research and the University of Chicago has identified an important site of vulnerability on influenza viruses—a site that future influenza ...

characterizing monoclonal antibodies, guiding vaccine formulation, and understanding immune recognition. It also plays a key role in optimizing antibody affinity, minimizing cross-reactivity, and ...

Generation of broad cytotoxic T-lymphocyte responses against multiple epitopes and tumor-associated antigens (TAAs) may provide effective immunotherapy in patients with cancer. We evaluated a ...

Professor Saar Gill and Professor Carl June from the Perelman School of Medicine at the University of Pennsylvania published a research paper titled: Epitope base editing CD45 in hematopoietic cells ...

This is a preview. Log in through your library . Abstract Certain single cells in carrot (Daucus carota L.) suspension cultures react with the monoclonal antibody JIM8, and it has been proposed that ...