Some single-celled organisms are known to transition to multicellularity during their lifetimes, usually either by cloning themselves or when many similar cells come together to form a larger ...

Centromeres play virtually the same central role across the entire tree of life: They ensure the faithful segregation of chromosomes during cell division. Yet the striking diversity in centromere ...

Cancer does not develop overnight. It can take decades for cancer-promoting changes in the genome to eventually lead to the formation of a malignant tumor. Researchers at the German Cancer Research ...

The integration of single-cell and spatial transcriptomics with advanced metabolic profiling tools has revolutionized the ...

Researchers at Moffitt Cancer Center have developed a new way to predict how cancer cells evolve by gaining and losing whole chromosomes, changes that help tumors grow, adapt and resist treatment. In ...

Single-cell RNA-seq (scRNA-seq) has spent the past decade maturing into a foundational technology. Over that time, the technology has both laid the foundation for building cell atlases and allowed ...

A new platform combines rational protein design with continuous evolution to discover functional molecules more efficiently. In medicine and biotechnology, the ability to evolve proteins with new or ...