It is well established that the aging heart progressively remodels towards a senescent phenotype, but alterations of cellular microstructure and their differences to chronic heart failure (HF) ...
Calcium (Ca²⁺) signalling is essential for cardiomyocyte function, regulating excitation–contraction coupling and excitation–transcription coupling, and contributing to mitochondrial energy production ...
The ability to modify the intracellular concentrations of divalent calcium ions is vital to normal cell functioning. In the cells of the cardiac muscle, calcium ions play a crucial role in coupling ...