Pragmatic clinical trials (PCTs) offer a promising alternative to explanatory trials, according to a recent commentary published in the ESMO Real World Data and Digital Oncology. Such trials feature ...

2. Trial visits are kept to a minimum with potential utilization of telemedicine or stipends increase attendance 3. Trial mimics typical clinical workflow with minimization of visits, and laboratory ...

Here, we review the principles, methodologies, challenges, and advantages of incorporating pragmatic features (PFs) into cancer clinical trials. We illustrate the application of pragmatic trial ...

The SWOG S2302 Pragmatica-Lung trial, which broke new ground with its streamlined pragmatic design, unusually broad eligibility criteria, and reduced data collection, has quickly answered its primary ...

The National Cancer Institute, part of the National Institutes of Health (NIH), has helped launch a phase 3 randomized clinical trial (NCT05633602) of a two-drug combination to treat patients with ...