If you're planning anything more than a rudimentary mod selection, grab the New Vegas Script Extender to enhance the power of subsequent mods, and the JIP LN NVSE Plugin for more engine-level bug ...

New Vegas in 2025 and have a grand time. Of course, you may start playing Fallout: New Vegas right away, without any mods, but the experience is likely marred by bugs, crashes, and outdated visuals.