Investigators exploring the genetic profile of a small number of adult ovarian granulosa cell tumors found that each had a specific missense point mutation in FOXL2 (402C > G [C134W]), a gene that had ...

An asymptomatic 66-year-old woman with metastatic breast carcinoma in the pelvis was recently diagnosed with a pelvic granulosa cell tumor with widespread peritoneal deposits. Histologically, both ...

Mature egg cells, or oocytes, are essential for fertilization in assisted reproductive technologies. However, some 'denuded' oocytes, or those lacking the protective granulosa cell layer, fail to ...

Forkhead box protein L2 (FOXL2) is a protein involved in ovary development and maintenance, among other functions. Mutations in its gene are involved in ovarian failure and granulosa cell tumors, ...

Low oxygen conditions while culturing rGOCs (reconstructed granulosa cell-oocyte complexes) increased oocyte diameters in vitro, and viable eggs were successfully produced using this method. Mature ...

In living organisms, cells are constantly sending and receiving signals. The most common form of communication is through chemical signals, such as hormones. In many body fluids, cells use ...

Communication between oocytes and granulosa cells is essential for oocyte formation, dormancy, reawakening, and maturation. Researchers have demonstrated that a protein complex called the exocyst ...

Mature egg cells, or oocytes, are essential for fertilization in assisted reproductive technologies. However, some 'denuded' oocytes, or those lacking the protective granulosa cell layer, fail to ...