For the first time scientists have identified promising drug candidates that bind irreversibly with a notoriously “undruggable” cancer protein target, permanently blocking it. Transcription factors ...
At the ongoing meeting of the American Chemical Society in Denver, F. Hoffmann-La Roche Ltd. has reported the discovery of an orally available and brain-penetrant irreversible asparagine-specific ...
Researchers from Johnson & Johnson presented the discovery of a novel inhibitor of cyclin-dependent kinase 7 (CDK7), a co-factor that controls transcription by phosphorylating the C-terminal domain of ...
A research team led by Prof. LIU Qingsong from the Hefei Institutes of Physical Science of the Chinese Academy of Science has developed IHMT-15130, a selective and irreversible inhibitor of Bone ...
The striking benefits achieved with emerging treatment options for recalcitrant connective tissue diseases offer the ...
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