Opioids slot into opioid receptors and activate them. This sends signals to your brain to relieve pain and promote pleasure. Both endogenous opioids, which your body naturally produces, and exogenous ...

Two different versions of the mu-opioid receptor within a cellular membrane illustrate how the receptor changes its conformation to send a signal into the cell. Scientists captured six high-resolution ...

Opioid drugs such as morphine and fentanyl produce their strong analgesic and adverse effects (in particular, respiratory depression and likelihood of abuse) by activating a G protein–coupled receptor ...

An internationally recognized leader in molecular pharmacology and neurobiology, Dr. Bohn recently joined USF Health. She is ...

No field more eagerly awaits a molecular clarification for G-protein coupled receptor (GPCR) dimerization than the opioid receptor field. Extensive evidence of pharmacological and functional ...

Nuclear receptors are popular targets for drug companies searching for new therapeutics for cancer and cardiovascular, metabolic, inflammatory, and other diseases. Indigo Biosciences in State College, ...

Endorphins became a household word in the late 1970s when Candace Pert and colleagues (Snyder & Simantov, 1977) at Johns Hopkins University School of Medicine made front-page news by identifying ...