Figure 1: Graphical illustration of the main findings from Pfeiffer et al., Cancer Research, 2022. The SH2 domain-containing tyrosine phosphatase 2 (SHP2) is a ubiquitously expressed non-receptor ...
The new study can help understanding diseases stemming from the abnormal functions of the human receptor tyrosine kinases, RTKs. Much of the cell-to-cell communication is facilitated in humans by 58 ...
Despite extensive efforts to characterize the genomes and proteomes of triple-negative breast cancer (TNBC), no dominantly-acting mutated RTK has emerged as a therapeutic target in TNBC. Instead, ...
In 2015, researchers at UC San Francisco found a structure inside of tumor cells that biologists had never seen before. Even more surprising, a closer examination of the structure revealed that it ...
Population pharmacokinetics (popPK) and exposure-response (ER) analyses bridge J-ALEX to the global population with an alectinib (ALC) 600mg bid dosing regimen. This is an ASCO Meeting Abstract from ...
In a recent study published in the journal EMBO Reports, researchers discussed and identified the systemic functions and interactions of 52 active cell surface receptor tyrosine kinases (RTKs), ...
Phase I/II study of PF-06463922, an ALK/ROS1 tyrosine kinase inhibitor, in patients with advanced non-small-cell lung cancer harboring specific molecular alterations. Background: MGCD516, is an orally ...
Receptor tyrosine kinases (RTKs) regulate many critical biological processes such as cell growth, differentiation, and survival through the recruitment of intracellular signaling molecules. The ...
Much of the cell-to-cell communication is facilitated in humans by 58 cell surface receptor tyrosine kinases (RTKs). In a study published in the EMBO Reports, Finnish research team led by Dr. Markku ...
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