Nature

Mismatch repair status may predict response to adjuvant chemotherapy in resectable pancreatic ductal adenocarcinoma

Deficiencies in DNA mismatch repair have been associated with inferior response to 5-FU in colorectal cancer. Pancreatic ductal adenocarcinoma is similarly treated with pyrimidine analogs, yet the ...
Nature

Assessing colorectal cancer mismatch repair status in the modern era: a survey of current practices and re-evaluation of the role of microsatellite instability testing

Approximately 15–18% of colorectal carcinomas show mismatch repair deficiency [1,2,3,4]. Most of these are sporadic tumors with epigenetic silencing of MLH1 expression through promoter ...
Medscape

Mismatch Repair Status Linked to Endometrial Cancer Outcomes, Real-World Study Reveals

A retrospective study found that patients with mismatch repair (MMR)-deficient advanced or recurrent endometrial cancer had numerically longer overall survival (OS) than those with MMR-proficient ...
ascopubs.org

Comparison of mismatch repair status between primary and matched metastatic sites in patients with colorectal cancer.

Update survival analysis from a multicenter, randomized phase 3 study on the optimization of the combination of bevacizumab with FOLFOX/OXXEL in patients with metastatic colorectal cancer (mCRC).