In amyotrophic lateral sclerosis and many cases of frontotemporal dementia, the RNA-binding protein TDP-43 abandons the nucleus and clumps up in cytoplasm, disrupting the normal workings of neurons ...
Neurodegenerative diseases, such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are medical conditions characterized by the progressive degradation ...
TDP-43 leads a varied life, interacting with a host of different RNAs and proteins as it shuttles from the nucleus to the cytoplasm and back. This offers this RNA-binding protein plenty of ...
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