The course of autosomal dominant polycystic kidney disease (ADPKD) is often associated with pain, hypertension, and kidney failure. Preclinical studies indicated that vasopressin V 2-receptor ...

Although tolvaptan bests fluid restriction at raising plasma sodium concentration, 19% of patients experience overcorrection ...

Please provide your email address to receive an email when new articles are posted on . The eGFR decline rate for patients on tolvaptan was –2.58 mL/min/1.73 m² per year. For patients in the control ...

Please provide your email address to receive an email when new articles are posted on . Patients on tolvaptan had an eGFR decline of 1.40 mL/min/1.73 m² per year. Annual rate of eGFR decline in ...

Chicago, IL - Results of two trials of tolvaptan (Otsuka America Pharmaceutical), a novel oral vasopressin V2-receptor antagonist, show that treatment effectively increased serum sodium concentrations ...

Results of the TEMPO 3:4 study, reported at ASN Kidney Week in San Diego, USA in November and published in the New England Journal of Medicine, have shown that tolvaptan may be useful in reducing ...

A study assessing tolvaptan efficacy in patients 35 years or younger found a 40% difference in eGFR decline compared with standard care. Tolvaptan initiation in adults aged 35 years or younger with ...

In a trial, low-dose tolvaptan was an effective second-line treatment in patients with hyponatremia from SIAD at high risk of fluid restriction failure. Rigorous monitoring is crucial. In trial ...

Discover comprehensive details about Tolvaptan, including its pronunciation, uses, dosage instructions, indications, and guidelines on how and when to take it or avoid it. The updated prescription ...

The Appraisal Committee reviewed the data available on the clinical and cost effectiveness of tolvaptan, having considered evidence on the nature of autosomal dominant polycystic kidney disease (ADPKD ...

Tolvaptan dosing was started in daily morning and afternoon doses of 45 mg and 15 mg, respectively, with weekly increases to 60 mg and 30 mg and then to 90 mg and 30 mg, according to patient-reported ...