More than 100 million people in the U.S. will be in the path of an intense March storm starting Friday as the sprawling multi-day system threatens fires, blizzards, tornadoes, and flooding as it tracks eastward across the Great Plains.

The forecast comes days after an expansive storm similarly trekked across the U.S. last week, unloading snow in the northern Plains and bringing tornadoes and wildfires to the South. At least five storm-related deaths in Nebraska and Mississippi were tied to that storm.

A potent storm system is expected to pour heavy rain on western states later this week before rumbling into the central United States