The data scientist’s goal is to simultaneously reduce bias and variance as much as possible in order to obtain as accurate model as is feasible. However, there is a tradeoff to be made when selecting ...

System-wide measurements of gene expression by DNA microarray and, more recently, RNA-sequencing strategies have become de facto tools of modern biology and have led to deep understanding of ...

This suggests that there is a substantial amount of variability or noise within the data. Consequently, estimates or predictions derived from the data are likely to ...

The Annals of Applied Statistics, Vol. 11, No. 4 (December 2017), pp. 2027-2051 (25 pages) Linear mixed models (LMMs) are among the most commonly used tools for genetic association studies. However, ...

Statistical genetic approaches to mapping genotype onto phenotype continue to place in a black box all the events occurring between the gene and the appearance of a trait. Despite the historical ...