Figure 1: Histone chaperones are key regulators of replication-coupled and replication-independent nucleosome assembly. Figure 2: H3–H4 histone chaperones bind a H3–H4 dimer or a (H3–H4) 2 tetramer.

Previous work showed that histone ‘readers’, which bind to post-translational modifications on histones, may be upregulated in melanoma and thereby upregulate oncogenes. Given that the histone reader ...

This Brush Up is sponsored by Cayman Chemical. Learn more about chemical inhibitors of histone modification. Histone modification affects how tightly DNA wraps around histone proteins, yielding ...

A new study shows how histones undergo correct chemical modifications during synthesis to guide new therapies.

Chromatin Immunoprecipitation Seqencing (ChIP-Seq) is a powerful tool that enables researchers to investigate and understand protein−DNA interactions and the influence these have on gene expression ...

Strands of DNA wrapped around a histone. Credit: Molekuul/Science Source Histones are among the most abundant proteins in the body. They act as spools that help compact DNA so our enormous genomes ...

CpG density and epigenetic modification state modulate DNA mechanics, altering its intrinsic compatibility with nucleosome formation.

Researchers identify hundreds of candidate histone proteins in bacteria, including one with an unusual way of binding to DNA. Now, Warnecke and colleagues are challenging the idea that these ...

In chromosomes, DNA is wrapped around proteins called histones. These histones are crucial for efficient packaging of DNA, as well as the replication and segregation of chromosomes themselves. Due to ...

The Warburg effect describes how cancer cells switch from oxidative phosphorylation to glycolysis even in oxygen-rich ...