In a recent interview with Entertainment Weekly, Bruckheimer revealed that he has spoken to Depp about coming back for the sixth Pirates film, and the actor is at least open to the idea. The famous Producer explained: If he likes the way the part's written,

The film’s producer shares whether he thinks the actor known for his iconic role as Captain Jack Sparrow could appear in the next film.

Bruckheimer previously told EW that he was eager for Depp to return to the role, despite Disney cutting ties with Depp, which the actor claimed happened as a result of the publication of a 2018 op-ed in which his ex-wife, Amber Heard, wrote that she had been a victim of domestic abuse but did not mention Depp by name.