Elevated WNT signalling triggers a wound-like response in RAS cancer cells, activating TLRs-dependent canonical NF-κB ...
The NEURL E3 ubiquitin ligases selectively activate the Notch ligands DLL1 and JAG1, but not DLL4 and JAG2. This differential ...
DnaK/DnaJ or Trigger factor and find that chaperone dependence during primary biogenesis in vivo does not track with ...
Amplified by social media, the overwhelmingly positive balance between population benefit and individual damage is forgotten. This has been the case for Covid vaccinations, where politics and health ...
Selective autophagy ensures the targeted degradation of damaged or surplus cellular components, including organelles, thereby ...
Stabilization of microtubule plus end-directed kinesin CENP-E at the metaphase kinetochores is important for chromosome alignment, but its mechanism remains unclear. Here, we show that CKAP5, a ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Atherosclerosis is characterized by the ...
Proteins are the key molecular machines that orchestrate all biological processes of the cell. Most proteins fold into three-dimensional shapes that are critical for their function. Studying the 3D ...
Centrioles are evolutionarily conserved barrels of microtubule triplets that form the core of the centrosome and the base of the cilium. While the crucial role of the proximal region in centriole ...
ER–mitochondria contact sites (ERMCSs) regulate processes, including calcium homoeostasis, energy metabolism and autophagy. Previously, it was shown that during growth factor signalling, mTORC2/Akt ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Protein complexes composed of strictly ...
“Pioneering” transcription factors open certain chromatin domains for regulatory complexes. Novel, genome‐wide results establish FoxA1, Hnf4α and AP‐2α as pioneer factors for the androgen‐receptor in ...
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