Mario Barrios is a -280 favorite to defeat Manny Pacquiao according to the odds at FanDuel Sportsbook. A bet on the underdog Pacquiao would pay out at +210. These odds suggest that Barrios has a 73.7% chance of winning the fight. When you consider the age and reach advantage he possesses, the betting odds seem about right.

At 46, Pacquiao is older than George Foreman when Foreman defeated Michael Moorer to win the IBF and WBA heavyweight titles in 1994. Pacquiao also hasn't fought professionally in just shy of four years, retiring after being beaten by Yordenis Ugas in August 2021. That Ugas fight came more than two years after Pacquiao's previous bout.

Manny Pacquiao returned to the ring for the first time in six years with the boxing legend taking on Mario Barrios at the MGM Grand in Las Vegas, his 16th fight at the famous arena