Adeno-associated virus (AAV) is widely used in gene therapy as a vector to deliver genetic material into patient cells due to its specificity and low immunogenicity. Accurate AAV quantification and ...

Neovascular age-related macular degeneration (nAMD) is a progressive eye disease characterized by choroidal neovascularization and subretinal hemorrhage and exudation, leading to vision impairment.

AAV relapse following transplantation significantly increased the risk of graft failure and may be linked to ANCA positivity. Kidney transplantation offered short-term outcomes comparable with ...

AstraZeneca’s rare disease unit Alexion has penned a $825 million deal for adeno-associated virus (AAV) capsids from existing partner JCR Pharmaceuticals to develop genomic medicines. Under the deal, ...

HYOGO, Japan--(BUSINESS WIRE)--JCR Pharmaceuticals Co., Ltd. (TSE 4552; “JCR”) today announced that it has entered into a license agreement with Alexion, AstraZeneca Rare Disease (“Alexion”), for ...

Accelerating and de-risking late pre-clinical drug development with the zebrafish tumor xenograft (ZTX) platform. Efficacy and safety data from Ph1b, dose optimization trial of two doses of TH1902 ...

Amid a reckoning for the gene therapy field, Vertex Pharmaceuticals has joined a growing list of companies paring back their research efforts around the adeno-associated virus (AAV) vectors used to ...

A systematic diagnostic approach should be used to differentiate AAV from multiple myeloma. An elderly patient who was initially suspected of having antineutrophil cytoplasmic antibody ...

For decades, the Amphibious Assault Vehicle (AAV) has been a cornerstone of the U.S. Marine Corps, transporting troops and cargo from ship to shore. With its 29-ton combat weight, armored protection, ...

Adeno-associated viruses (AAVs) are used in nearly a dozen FDA-approved therapies and more than 900 R&D projects to deliver therapeutic payloads to cells. Yet, large-scale AAV production is still a ...