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emcrit.org
Wernicke encephalopathy
CONTENTS Rapid Reference Pathophysiology Signs & Symptoms Risk factors Epidemiology Laboratory studies Imaging Differential diagnosis & securing the diagnosis Prevention Treatment Prognosis Related topics Metronidazole-induced encephalopathy (MIE) Thiamine pharmacology biochemistry Thiamine is a co-factor in numerous enzymatic reactions ...
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PW MedEd on Instagram: "🧠 Understanding Wernicke’s Korsakoff Syndrome (WKS) 📍 What is WKS? A neuropsychiatric disorder combining Wernicke Encephalopathy (WE) and Korsakoff Syndrome, often seen in chronic alcoholism. 📘 Biochemistry Viewpoint: Cause: Thiamine (Vitamin B1) deficiency ➡️ impaired glucose metabolism. Markers: Elevated lactate & impaired pyruvate dehydrogenase. Treatment: Parenteral thiamine BEFORE glucose. 📡 Radiology Viewpoint: MRI Findings: Hyperintensities in mammillary bodies
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During horizontal gaze, the medial longitudinal fasciculus (MLF) on each side of the brain stem enables abduction of one eye to be coordinated with adduction of the other. The MLF connects the following structures: Sixth cranial nerve nucleus (which controls the lateral rectus, responsible for abduction) Adjacent horizontal gaze center (paramedian pontine reticular formation) Contralateral third cranial nerve nucleus (which controls the medial rectus, responsible for adduction) The MLF also conn
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