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Utilizing Cell-Free DNA Technologies
#Pathology #OrganTransplant Donor-derived cell-free DNA (dd-cfDNA) is emerging as a clinically validated, noninvasive biomarker with high negative predictive value—helping rule out rejection and detect early allograft injury. CAP experts Annette Sunhi Kim, MD, PhD, FCAP, and Julianne Szczepanski, MD, FCAP, unpack the science and evolving role ...
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Prenatal screening for fetal aneuploidy can be performed by analyzing cell-free DNA (cfDNA) in maternal blood, which derives from both maternal and placental sources during pregnancy. Placental cfDNA is rapidly cleared from the maternal circulation after delivery, thus cfDNA test results in future pregnancies are not affected by prior pregnancies. No result rates generally fall between 1 and 3 percent. Maternal plasma must contain an adequate amount of fetal cfDNA (fetal fraction) to obtain a re
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